Takaaki Abe Selected Research

Tryptophanase

1/2022

(+)-Sesamin, a sesame lignan, is a potent inhibitor of gut bacterial tryptophan indole-lyase that is a key enzyme in chronic kidney disease pathogenesis.

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Takaaki Abe Research Topics

Disease

14	Chronic Renal Insufficiency 01/2022 - 09/2011
11	Renal Insufficiency (Renal Failure) 12/2021 - 12/2009
10	Hypertension (High Blood Pressure) 01/2022 - 09/2003
9	Inflammation (Inflammations) 03/2022 - 12/2009
9	Neoplasms (Cancer) 12/2021 - 12/2003
8	Mitochondrial Diseases (Mitochondrial Disease) 03/2022 - 01/2015
7	Fibrosis (Cirrhosis) 12/2021 - 01/2012
6	Ischemia 01/2019 - 01/2013
5	Proteinuria 01/2021 - 09/2003
5	Renal Artery Obstruction (Renal Artery Stenosis) 11/2010 - 03/2005
4	Breast Neoplasms (Breast Cancer) 12/2021 - 10/2007
4	Adenoma (Adenomas) 11/2007 - 07/2006
3	Kidney Diseases (Kidney Disease) 03/2022 - 04/2011
3	Reperfusion Injury 01/2019 - 01/2016
3	Carcinoma (Carcinomatosis) 09/2008 - 07/2007
3	Heart Failure 03/2004 - 10/2003
2	Infarction (Infarctions) 01/2022 - 01/2020
2	Dysbiosis 12/2021 - 08/2015
2	Diabetic Nephropathies (Diabetic Nephropathy) 12/2021 - 01/2019
2	Type 2 Diabetes Mellitus (MODY) 12/2021 - 01/2013
2	COVID-19 01/2021 - 01/2020
2	Gout 01/2020 - 01/2020
2	Hyperuricemia 01/2020 - 01/2020
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2020 - 09/2011
2	Stroke (Strokes) 01/2020 - 01/2019
2	Colonic Neoplasms (Colon Cancer) 01/2019 - 01/2008
2	Gitelman Syndrome 11/2017 - 02/2015
2	Fibromuscular Dysplasia 10/2017 - 10/2007
2	Pathologic Constriction (Stenosis) 10/2017 - 10/2007
2	Renovascular Hypertension (Goldblatt Syndrome) 10/2017 - 03/2005
2	Chronic Kidney Failure (Chronic Renal Failure) 09/2017 - 09/2003
2	Body Weight (Weight, Body) 09/2017 - 01/2013
2	Acute Kidney Injury (Acute Renal Failure) 01/2017 - 01/2017
2	Hepatocellular Carcinoma (Hepatoma) 01/2015 - 09/2008
2	Transfusion Reaction 08/2014 - 11/2011
2	Autosomal Recessive Polycystic Kidney (Polycystic Kidney Disease, Infantile, Type I) 01/2013 - 01/2012
2	Insulin Resistance 01/2013 - 01/2010
2	Cardiomegaly (Heart Hypertrophy) 09/2011 - 12/2009
2	Colorectal Neoplasms (Colorectal Cancer) 09/2008 - 01/2008
2	Hypokalemia 01/2008 - 06/2007
1	Peritoneal Fibrosis 03/2022

Drug/Important Bio-Agent (IBA)

11	Uremic ToxinsIBA 02/2021 - 12/2009
10	Pharmaceutical PreparationsIBA 01/2021 - 08/2005
7	ReninIBA 01/2021 - 10/2003
7	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2007
6	Transfer RNA (tRNA)IBA 01/2022 - 10/2014
6	Adenine FDA LinkGeneric 12/2021 - 08/2015
6	Biomarkers (Surrogate Marker)IBA 11/2019 - 09/2011
6	Messenger RNA (mRNA)IBA 01/2017 - 03/2002
6	AldosteroneIBA 01/2008 - 09/2003
5	Adenosine Triphosphate (ATP)IBA 06/2017 - 03/2014
4	4- (2,4- difluorophenyl)- 2- (1H- indol- 3- yl)- 4- oxobutanoic acidIBA 03/2022 - 01/2015
4	EnzymesIBA 01/2022 - 09/2015
4	Sulfates (Sulfates, Inorganic)IBA 12/2021 - 01/2018
4	CreatinineIBA 01/2021 - 10/2003
3	indoleacetic acid (indole acetic acid)IBA 03/2022 - 01/2015
3	Antihypertensive Agents (Antihypertensives)IBA 01/2022 - 06/2007
3	SaltsIBA 01/2022 - 03/2014
3	Glucose (Dextrose)FDA LinkGeneric 12/2021 - 01/2013
3	Amino Acids FDA Link 12/2021 - 01/2017
3	Indicators and Reagents (Reagents)IBA 12/2021 - 03/2009
3	Uric Acid (Urate)IBA 01/2020 - 06/2010
3	AST 120IBA 01/2020 - 11/2012
3	indoleIBA 01/2019 - 01/2016
3	Mitochondrial DNA (mtDNA)IBA 01/2018 - 01/2015
3	AnionsIBA 03/2014 - 09/2011
3	CationsIBA 03/2014 - 07/2007
3	Bile Acids and Salts (Bile Acids)IBA 09/2008 - 10/2007
3	Doxorubicin (Adriamycin)FDA LinkGeneric 07/2007 - 08/2005
2	Amino Acid Transport Systems (Amino Acid Transporter)IBA 12/2021 - 08/2021
2	Tyrosine (L-Tyrosine)FDA Link 12/2021 - 01/2019
2	Phenol (Carbolic Acid)FDA Link 12/2021 - 01/2019
2	Phenobarbital (Luminal)FDA Link 12/2021 - 04/2011
2	Hormones (Hormone)IBA 08/2021 - 10/2007
2	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2020 - 01/2019
2	Volatile Fatty AcidsIBA 12/2019 - 01/2017
2	AntibodiesIBA 01/2019 - 08/2014
2	1-methyladenosineIBA 01/2019 - 01/2019
2	IndicanIBA 10/2018 - 11/2016
2	N,N-dimethylarginine (asymmetric dimethylarginine)IBA 09/2017 - 12/2009
2	Phosphotransferases (Kinase)IBA 01/2017 - 01/2008
2	AntioxidantsIBA 01/2016 - 01/2015
2	Transcription Factors (Transcription Factor)IBA 12/2015 - 09/2008
2	Biological ProductsIBA 09/2014 - 10/2007
2	Immunoglobulin E (IgE)IBA 08/2014 - 11/2011
2	Organic Anion TransportersIBA 03/2014 - 12/2009
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2013 - 01/2012
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 09/2011 - 12/2004
2	Pravastatin (Pravachol)FDA LinkGeneric 01/2010 - 12/2009
2	Solute Carrier Organic Anion Transporter Family Member 1B3IBA 01/2008 - 10/2007
2	Losartan (Cozaar)FDA LinkGeneric 10/2007 - 06/2007
1	chlorhexidine gluconate (Dyna-Hex)FDA LinkGeneric 03/2022
1	LignansIBA 01/2022
1	TryptophanaseIBA 01/2022
1	sesaminIBA 01/2022
1	PrebioticsIBA 01/2022

Therapy/Procedure

13	Therapeutics 08/2021 - 10/2003
2	Drug Therapy (Chemotherapy) 12/2021 - 02/2008
1	Intraperitoneal Injections 03/2022
1	Peritoneal Dialysis 03/2022